5/11/2021 0 Comments
Omega-3 polyunsaturated fatty acids (n3-PUFAs) are important mediators of inflammation and acquired immune responses and can amplify anti-inflammatory responses . Recent studies have been shown that n3-PUFAs including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linoleic acid (ALA) can increase the stability of the cell membrane, regulate immune function, block hyper inflammatory reactions, and reduce the incidence of systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and complications of infection .
Study Published in Journal of Translational Medicine examine the effect of n3-PUFA supplementation on inflammatory and biochemical markers in critically ill patients with COVID-19. Omega-3 supplementation improved the levels of several parameters of respiratory and renal function in critically ill patients with COVID-19.
In this study 128 critically ill patients infected with COVID-19 who were randomly assigned to the intervention (fortified formula with n3-PUFA) (n = 42) and control (n = 86) groups. Data on 1 month survival rate, blood glucose, sodium (Na), potassium (K), blood urea nitrogen (BUN), creatinine (Cr), albumin, hematocrit (HCT), calcium (Ca), phosphorus (P), mean arterial pressure (MAP), O2 saturation (O2sat), arterial pH, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), bicarbonate (HCO3), base excess (Be), white blood cells (WBCs), Glasgow Coma Scale (GCS), hemoglobin (Hb), platelet (Plt), and the partial thromboplastin time (PTT) were collected at baseline and after 14 days of the intervention. The intervention group had significantly higher 1-month survival rate and higher levels of arterial pH, HCO3, and Be and lower levels of BUN, Cr, and K compared with the control group after intervention (all P < 0.05). There were no significant differences between blood glucose, Na, HCT, Ca, P, MAP, O2sat, PO2, PCO2, WBCs, GCS, Hb, Plt, PTT, and albumin between two groups.
Marcelo M. Rogero, Matheus de C. Leão, Tamires M. Santana, Mariana V. de M.B. Pimentel, Giovanna C.G. Carlini, Tayse F.F. da Silveira, Renata C. Gonçalves, Inar A. Castro,Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19, Free Radical Biology and Medicine, Volume 156,2020,Pages 190-199,ISSN 0891-5849,
Inflammation is critical for COVID-19 patients.
Omega-3 fatty acids can decrease inflammation.
Clinical studies must consider omega-3 fatty acids as a co-therapy in COVID-19. 
Zhao Y, Wang C. Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: a meta-analysis of randomized control trials in China. Medicine. 2018;97(16):e0472.
Marcelo M. Rogero, Matheus de C. Leão, Tamires M. Santana, Mariana V. de M.B. Pimentel, Giovanna C.G. Carlini, Tayse F.F. da Silveira, Renata C. Gonçalves, Inar A. Castro,Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19,Free Radical Biology and Medicine,Volume 156, 2020,Pages 190-199,ISSN 0891-5849,